Major holdings in the University Archives and Records Program include the papers of the following physicians and hospital administrators: Medical Center Chancellor (1947-2003); Peter P. Bosomworth and James W. Holsinger, Jr. (1960–2003); Donald L. Hochstrasser (1975-1997); and Richard S. Schweet (1959-1964). College of Dentistry Dean (c. 1961-1992); David S. Carter (1982-1985); Emmett R. Costich (1962-1986); and Robert H. Spedding (1962-1977). College of Medicine Dean (1961-2005); N. K. Burki (1987-1993); John Sharpe Chambers (1910-1971); Joseph Engelberg (c. 1961-1972); Gilbert H. Friedell (1953-2005); Robert C. Noble (1993-1995); Joseph W. Pryor (1886-1956); Morris Scherago (1950-1971); George W. Schwert (1960-1971); Charles A. Vance (c. 1925-1959); David S. Watt (1989-2002); William R. Willard (1956-1972); Thomas F. Whayne (c. 1963-1988); and Abraham Wikler (c. 1940-1980). College of Nursing Dean (1956-2007) and Continuing Education (1965-1973). College of Pharmacy Dean (1860-1998); Richard M. Doughty (1947-1983); and Howard Hopkins (1955-1976). University Health Services (1929-1994). The Collection includes the papers of several women health workers: Jean Cox (1964-1978); Juanita W. Fleming (1976-1990); and Laia Hanau (1933-1991). Holdings also include scrapbooks and informational collections related to the Medical Center and Hospital construction: Medical Center construction scrapbook (1958-1960); UK HealthCare hospital construction (2005-2010). In addition the University Archives houses numerous theses, dissertations, publications, photographs, and writings on medical issues, including the important essay, Development of the bones of the hand, as shown by the X-ray method, by Joseph W. Pryor, 1905.

Approximately 246 cubic feet of archival materials.